Our data indicate that OT is necessary for the normal development of social memory in mice and support the hypothesis that social memory has a neural basis distinct from other forms of memory. The social behaviour of the stimulus females directed at Oxt/ versus Oxt+/+ male mice during these tests did not differ. Here, we evaluated the therapeutic potential of the pro-social, anti-inflammatory hormone, oxytocin, using social and non-social memory tasks in APP/PS1 mice. Treatment with OT but not AVP rescued social memory in Oxt-/- mice, and treatment with an OT antagonist produced a social amnesia-like effect in Oxt+/+ mice. Spatial memory and behavioural inhibition measured in a Morris water-maze, Y-maze, or habituation of an acoustic startle also seemed intact. Measurement of both olfactory foraging and olfactory habituation tasks indicated that olfactory detection of non-social stimuli is intact in Oxt-/- mice. We found that male mice mutant for the oxytocin gene (Oxt-/-) failed to develop social memory, whereas wild-type (Oxt+/+) mice showed intact social memory. CA Pedersen, Biological aspects of social bonding and the roots of human violence. The role of oxytocin in female social behavior. Pharmacological studies indicate that AVP administration may enhance social memory, whereas OT administration may either inhibit or facilitate social memory depending on dose, route or paradigm. JN Ferguson, et al., Social amnesia in mice lacking the oxytocin gene. A more general role for oxytocin in social behaviors is suggested by the social amnesia of oxytocin mutant mice ( 3) and by altered social decision-making in humans after oxytocin administration ( 4 ). Social amnesia in mice lacking the oxytocin gene Jennifer N. It is affected by oxytocin, and mice without the gene to produce that brain protein are said to suffer from 'social amnesia' and an inability to recognize 'familiar' mice.' The role of oxytocin in the amygdala in facilitating social recognition and bonding as well as how oxytocin receptor antagonists might induce social amnesia has also been. Here the authors demonstrate that observational fear, a measure of empathy-like behaviour in rodents, is modulated by oxytocin. Brain oxytocin (OT) and vasopressin (AVP) seem to modulate a range of social behaviour from parental care to mate guarding. Oxytocin modulates social behaviours in mammals. Researchers have operationally defined this memory by a reliable decrease in olfactory investigation in repeated or prolonged encounters with a conspecific. Oxytocin and social memory Social amnesia in mice lacking the oxytocin geneĭepartment of Psychiatry and Behavioural SciencesĪnd Yerkes Regional Primate Research Center,Įmory University School of Medicine, Atlanta, Georgia, USA.ĪBSTRACT The development of social familiarity in rodents depends predominantly on olfactory cues and can critically influence reproductive success.
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